This tool has the aim of aiding structure-based exploration by using all the gathered information from different third-party databases that are pertinent to a given variant of interest, creating a sharable Michelaɴɢʟo page (see Citation for how to cite specific datasets).


The analysis runs in five steps.

  1. The first step gets the information of protein, such as the features and sequence,
  2. The second step gives the effect of the mutation independent of the structural data,
  3. The third step gives the location and neighbourhood of the residue,
  4. The fourth step gives the change in energy potential resulting from the target mutation,
  5. The fifth step gives a crude change in energy potential for all the gnomAD mutations known in gomAD control dataset


  1. For a description of how VENUS chooses the model see model choice
  2. For a description of the VENUS specific API routes and the redirect routes see URLs
  3. For an explanation of the free energy calculations see free energy


VENUS stands for Variant Effect oN Structure —no, the U is not there.