Michelanglo — VENUS

Variant effect on structure


Aim

This tool has the aim of aiding structure-based exploration by using all the gathered information from different third-party databases that are pertinent to a given variant of interest, creating a sharable Michelaɴɢʟo page (see Citation for how to cite specific datasets).

Parts

The analysis runs in five steps.

  1. The first simply gets the information of protein, such as the feature viewer,
  2. The second gives the effect of the mutation independent of the structural data,
  3. The third gives the location and neighbourhood of the residue,
  4. The fourth gives the change in energy potential resulting from the mutation,
  5. The fifth gives a crude change in energy potential resulting from the gnomAD mutations known in gomAD

Details

  1. For a description of how VENUS chooses the model see VENUS model
  2. For a description of the VENUS specific API routes and the redirect routes see VENUS URLs
  3. For an explanation of the free energy calculations see VENUS energetics

Name

VENUS stands for Variant Effect oN Structure —no, the U is not there.