Lysine Demethylase JMJD1B (KDM3B)The content of this page was edited by SGC and matteoferla on the 2019-10-07 15:59:05.680785.
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There are 3 members of the Lysine Demethylase JMJD1 (KDM3) family, JMJD1A-C. SGC Oxford has expressed, purified and crystallized the catalytic domains of JMJD1A, JMJD1B and JMJD1C as part of the probe programme. Fragment screening and X-ray crystallography identified a large number of binders, some of which were progressed into a medicinal chemistry programme. Despite significant effort molecules with probe properties were not obtained. Consequently it has been decided to put the information generated into the public domain.
Structures available in TEP:
- Crystal structure of JmjC domain of KDM3B (PDB:4C8D ): ,
- Crystal structure of JMJD1C catalytic domain (PDB:5FZO ): ,
- Crystal structure of JMJD1C Jumonji domain (PDB:2YPD ): ,