Human Pleckstrin Homology Domain Interacting Protein (PHIP)
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TEP details
Summary
SGC Oxford has expressed, purified and crystallized the second bromodomain of PHIP as part of the probe programme. Fragment screening and X-ray crystallography identified binders, some of which optimised to micromolar affinity. However, molecules with probe properties were not obtained. Consequently it has been decided to put the information generated into the public domain.
Structures
Structures available in TEP:
- Structure of PHIP bromodomain (PDB:3MB3 ): protein, ligand
- PHIP bromodomain in complex with fragment (PDB:5ENB ): protein, ligand
- PHIP bromodomain in complex with fragment (PDB:5ENC ): protein, ligand
- PHIP bromodomain in complex with fragment (PDB:5ENE ): protein, ligand
- PHIP bromodomain in complex with fragment (PDB:5ENF ): protein, ligand
- PHIP bromodomain in complex with fragment (PDB:5ENH ): protein, ligand
- PHIP bromodomain in complex with fragment (PDB:5ENI ): protein, ligand
- PHIP bromodomain in complex with fragment (PDB:5ENJ ): protein, ligand