HICF2: SLC39A13 D228H
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Model warning One or more structures presented here are computational models and not experimental determinations, consequently should be treated with caution.
This is a cation transporter in the ER. It either transports zinc out of the ER into the cytosol or it transports iron into the ER.
It is unclear whether it is a channel (more correctly, passive carrier) or a active transporter (symporter or exchanger, but not ATP-driven transporter). It most likely forms a dimer based on some other homologues.
The mutation affects zinc binding to entrance by closing up the pore.
- D228H (wild type/mutant)