Human Histone Deacetylase 6 (HDAC6)
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TEP details
Summary
HDAC6 is a cytosolic deacetylase with diverse roles in cellular trafficking, autophagy and cell signalling. Specifically targeting the unique zinc-finger ubiquitin-binding domain (ZnF-UBD) of HDAC6 may be an attractive strategy in myeloma and lymphoma but no inhibitor has been reported to date. Presented here are 4 co-crystal structures of HDAC6 ZnF-UBD in complex with different compounds, and associated SPR, ITC and FP assays.
Structures
Structures available in TEP:
- Crystal structure of HDAC6 (PDB:6CE6 ): protein, ligand
- Fragment bound in ubiquitin binding pocket of HDAC6 zinc finger domain (PDB:5KH3 ): protein, ligand
- Fragment bound in ubiquitin binding pocket of HDAC6 zinc finger domain (PDB:5KH7 ): protein, ligand
- Fragment bound in ubiquitin binding pocket of HDAC6 zinc finger domain (PDB:5KH9 ): protein, ligand
- Fragment bound adjacent to ubiquitin binding pocket of HDAC6 zinc finger domain (PDB:5B8D ): protein, ligand
- Fragment bound in ubiquitin binding pocket of HDAC6 zinc finger domain (PDB:5WPB ): protein, ligand
- Fragment bound in ubiquitin binding pocket of HDAC6 zinc finger domain (PDB:5WBN ): protein, ligand
- Fragment bound in ubiquitin binding pocket of HDAC6 zinc finger domain (PDB:6CE8 ): protein, ligand
- Fragment bound in ubiquitin binding pocket of HDAC6 zinc finger domain (PDB:6CEC ): protein, ligand
- Fragment bound in ubiquitin binding pocket of HDAC6 zinc finger domain (PDB:6CED ): protein, ligand
- Fragment bound in ubiquitin binding pocket of HDAC6 zinc finger domain (PDB:6CEE ): protein, ligand
- Fragment bound in ubiquitin binding pocket of HDAC6 zinc finger domain (PDB:6CEF ): protein, ligand