Human Peroxisomal Coenzyme A Diphosphatase NUDT7 (NUDT7)
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TEP details
Summary
In an effort to characterise the human NUDIX family SGC Oxford has expressed recombinant human NUDT7 as part of the SGC chemical probe programme and solved the first crystal structure of this enzyme. This enabled a crystallographic fragment screen which in conjunction with a separate covalent fragment approach yielded a first-in-class small molecule inhibitor of NUDT7 with activity in the single-digit micromolar range in a catalytic assay. This compound paves the way for chemical probe development and further functional exploration of NUDT7 in physiological and disease contexts.
Structures
Structures available in TEP:
- Structure of Human Peroxisomal coenzyme A diphosphatase NUDT7 (PDB:5T3P ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QGG ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QGH ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QGI ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QGJ ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QGK ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QGL ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QGM ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QGN ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QGO ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QGP ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QGQ ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QGR ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QGS ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QGT ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QGU ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QGV ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QGW ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QGX ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QGY ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QGZ ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QH0 ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QH1 ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QH2 ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QH3 ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QH4 ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QH5 ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QH6 ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QH7 ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QHF ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QH8 ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QH9 ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QHA ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QHG ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QHH ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QHB ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QHC ): protein, ligand
- NUDT7 in complex with fragment (PDB:5QHE ): protein, ligand