5'-Aminolevulinate synthase, erythoid-specific (ALAS2)
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TEP details
Summary
Erythorid specific 5’-Aminolevulinate synthase (ALAS2) catalyses the first and rate-determining step in haem biosynthesis during erythroid development. This TEP provides the structural biology tools to facilitate two aspects of ALAS2 research: (i) understand how mutations in the ALAS2 C-terminus, a region unique to higher eukaryotes, lead to over-activity of the enzyme associated with a gain-of-function disorder; and (ii) providing chemical starting points to explore metabolic intervention of ALAS2, as substrate reduction therapy for the group of porphyria disorders that are associated with haem biosynthetic steps downstream of ALAS2.
Structures
Structures available in TEP:
- Structure of hsALAS2 bound with PLP (PDB:6HRH ): protein, ligand
- Structure of hsALAS2 bound with PLP and fragment 1 (x1131): (PDB:5QQY ): protein, ligand
- Structure of hsALAS2 bound with PLP and fragment 2 (x1154):N-(cyclobutylmethyl)-1,5-dimethyl-1H-pyrazole-4-carboxamide (PDB:5QR1 ): protein, ligand
- Structure of hsALAS2 bound with PLP and fragment 3 (x1277): (PDB:5QRA ): protein, ligand
- Structure of hsALAS2 bound with PLP and fragment 4 (x1311): (PDB:5QRC ): protein, ligand
- Structure of hsALAS2 bound with PLP and fragment 5 (x1317): (PDB:5QRD ): protein, ligand
- Structure of hsALAS2 bound with PLP and fragment 6 (x1084): (PDB:5QQW ): protein, ligand
- Structure of hsALAS2 bound with PLP and fragment 7 (x1097): (PDB:5QQX ): protein, ligand
- Structure of hsALAS2 bound with PLP and fragment 8 (x1359): (PDB:5QRE ): protein, ligand
- Structure of hsALAS2 bound with PLP and fragment 9 (x1082): (PDB:5QQU ): protein, ligand
- Structure of hsALAS2 bound with PLP and fragment 10 (x1036): (PDB:5QQQ ): protein, ligand
- Structure of hsALAS2 bound with PLP and fragment 11 (x1147):N-benzyl-1-methyl-1H-pyrazol-3-amine (PDB:5QR0 ): protein, ligand
- Structure of hsALAS2 bound with PLP and fragment 12 (x1235): (PDB:5QR9 ): protein, ligand
- Structure of hsALAS2 bound with PLP and fragment 13 (x1208):N-phenethyl-1H-benzo[d]imidazol-2-amine (PDB:5QR7 ): protein, ligand
- Structure of hsALAS2 bound with PLP and fragment 14 (x1080): (PDB:5QQT ): protein, ligand
- Structure of hsALAS2 bound with PLP and fragment 15 (x1070): (PDB:5QQS ): protein, ligand
- Structure of hsALAS2 bound with PLP and fragment 16 (x1141): (PDB:5QQZ ): protein, ligand
- Structure of hsALAS2 bound with PLP and fragment 17 (x1185): (PDB:5QR4 ): protein, ligand
- Structure of hsALAS2 bound with PLP and fragment 18 (x1196): (PDB:5QR5 ): protein, ligand
- Structure of hsALAS2 bound with PLP and fragment 19 (x1281): (PDB:5QRB ): protein, ligand